Sulfagenix's Publications

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Anti-inflammatory and antiviral roles of hydrogen sulfide: Rationale for considering H2S donors in COVID-19 therapy

Valentina Citi, Alma Martelli, Vincenzo Brancaleone, Simone Brogi, Gabriel Gojon, Rosangela Montanaro, Guillermo Morales, Lara Testai, Vincenzo Calderone. BJP British Journal of Pharmacology 2020, Volume 177, Issue 21, pages 4931-4941

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On H2S Prodrugs

Gabriel Gojon.Antioxidants & Redox Signaling.Nov 2020.999-1002

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SG1002 and Catenated Divalent Organic Sulfur Compounds as Promising Hydrogen Sulfide Prodrugs

Dr. Gabriel Gojón and Dr. Guillermo A. Morales. Antioxidants & Redox Signaling 2020, Volume 33, Number 14, pages 1010-1045

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SG1002 Publications

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H2S Prodrug, SG-1002, Protects Against Myocardial Oxidative Damage and Hypertrophy via Induction of Cystathionine β-Synthase and Antioxidant Proteins

Rahib K. Islam, Erinn Donnelly, Fokhrul Hossain, Jason D. Gardner, Kazi N. Islam. bioRxiv 2021.03.28.437435

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Hydrogen Sulfide Ameliorates Homocysteine-Induced Cardiac Remodeling and Dysfunction
Sumit Kar, Hamid R. Shahshahan, Tyler N. Kambis, Santosh K. Yadav, Zhen Li, David J. Lefer and Paras K. Mishra. Front Physiol. 2019, vol 10:598.

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Restoration of Contractile Protein Expression and Colonic Smooth Muscle Function by H2S in Duchenne Muscular Dystrophy Mice
Kulpreet Singh, Gurpreet Randhawa, Sunila Mahavadi, Chad Cain, Fadi N Salloum, John R Grider, and Karnam S Murthy (The FASEB Journal, 2019, vol. 33, No. 1 supplement)​.

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Hydrogen Sulfide Improves Aberrant Gastric Smooth Muscle Function in Duchenne Muscular Dystrophy Mice
Gurpreet Randhawa, Kulpreet Singh, Sunila Mahavadi, Chad Cain, Fadi N Salloum, Karnam S Murthy, and John R Grider (The FASEB Journal, 2019, Vol. 33, No. 1 supplement).​​

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Prevention and Treatment of Duchenne Cardiomyopathy with Hydrogen Sulfide-Donor Therapy
Chad Cain, Teja Devarakonda, Jeremy Thompson, Qun Chen, Lorren Cain, Jared Farrar, Geronimo Guzman, Francesco Celi, Edward J Lesnefsky, and Fadi N Salloum (The FASEB Journal, 2019, Vol. 33, No. 1 supplement).​

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Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis
Bibli SI, Hu J, Sigala F, Wittig I, Heidler J, Zukunft S, Tsilimigras D, Randriamboavonjy V, Wittig J, Kojonazarov B, Schürmann C, Siragusa M, Siuda D, Luck B, Abdel Malik R, Filis KA, Zografos G, Chen C, Wang DW, Pfeilschifter J, Brandes RP, Szabo C, Papapetropoulos A, Fleming I.  Circulation. 2019 Jan 2;139(1):101-114. doi: 10.1161/CIRCULATIONAHA.118.034757

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A Novel Hydrogen Sulfide Prodrug, SG1002, Promotes Hydrogen Sulfide and Nitric Oxide Bioavailability in Heart Failure Patients

Polhemus DJ, Li Z, Pattillo CB, Goodchild TT, Gojon G Sr, Gojon G Jr, Giordano T, Krum H.  Cardiovasc Ther. 2015 Apr 29.

 

A randomized clinical study assessing the effects of the antioxidants , resveratrol or SG1002 , a hydrogen sulfide prodrug , on idiopathic oligoasthenozoospermia

Arturo Morales Martinez et al. Asian pacific journal of reproduction, 2015 vol 4(2):106-111

 

Hydrogen sulfide attenuates high fat diet-induced cardiac dysfunction via the suppression of endoplasmic reticulum stress

Barr LA, Shimizu Y, Lambert JP, Nicholson CK, Calvert JW. Nitric Oxide. 2015 Apr 30;46:145-56.

 

H₂S Protects Against Pressure Overload-Induced Heart Failure via Upregulation of Endothelial Nitric Oxide Synthase

Kondo K, Bhushan S, King AL, Prabhu SD, Hamid T, Koenig S, Murohara T, Predmore BL, Gojon G Sr, Gojon G Jr, Wang R, Karusula N, Nicholson CK, Calvert JW, Lefer DJ. Circulation. 2013 Mar 12;127(10):1116-27. doi: 10.1161/CIRCULATIONAHA.112.000855. Epub 2013 Feb 7.

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Hydrogen Sulfide Role in Health and Disease

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Total Plasma Sulfide in Congestive Heart Failure

Kovačić D, Glavnik N, Marinšek M, Zagožen P, Rovan K, Goslar T, Marš T, Podbregar M. J Card Fail. 2012 Jul;18(7):541-8.

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Are We Getting Enough Sulfur in Our Diet?

Nimni ME, Han B, Cordoba F. Nutr Metab (Lond). 2007 Nov 6;4:24.

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Hydrogen Sulfide Mechanism of Action

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Hydrogen Sulfide Cytoprotective Signaling is Endothelial Nitric Oxide Synthase-Nitric Oxide Dependent

King AL, Polhemus DJ, Bhushan S, Otsuka H, Kondo K, Nicholson CK, Bradley JM, Islam KN, Calvert JW, Tao YX, Dugas TR, Kelley EE, Elrod JW, Huang PL, Wang R, Lefer DJ. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3182-7. doi: 10.1073/pnas.1321871111. Epub 2014 Feb 10.

 

 

Hydrogen Sulfide Attenuates Cardiac Dysfunction After Heart Failure via Induction of Angiogenesis

Polhemus DJ, Kondo K, Bhushan S, Bir SC, Kevil CG, Murohara T, Lefer DJ, Calvert JW. Circ Heart Fail. 2013 Sep 1;6(5):1077-86. doi: 10.1161/CIRCHEARTFAILURE.113.000299. Epub 2013 Jun 28.

 

The Polysulfide Diallyl Trisulfide Protects the Ischemic Myocardium by Preservation of Endogenous Hydrogen Sulfide and Increasing Nitric Oxide Bioavailability

Predmore BL, Kondo K, Bhushan S, Zlatopolsky MA, King AL, Aragon JP, Grinsfelder DB, Condit ME, Lefer DJ. Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2410-8.

 

Hydrogen Sulfide Attenuates Myocardial Ischemia-Repurfusion Injury by Preservation of Mitochondrial Function

Elrod JW, Clavert JW, Morrison J, Doeller JE, Kraus DW, Tao L, Jiao X, Scalia R, Kiss L, Szabo C, Kimura H, Lefer DJ. Proc Natl Acad Sci U S A. 2007 Sept 25;104(39):15560-15565. 

 

Genetic and Pharmacologic Hydrogen Sulfide Therapy Attenuates Ischemia-Induced Heart Failure in Mice

Calvert JW, Elston M, Nicholson CK, Gundewar S, Jha S, Elrod JW, Ramachandran A, Lefer DJ. Circulation. 2010 Jul 6;122(1):11-9. doi: 10.1161/CIRCULATIONAHA.109.920991. Epub 2010 Jun 21.

 

Hydrogen Sulfide Improves Survival After Cardiac Arrest and Cardiopulmonary Resuscitation via a Nitric Oxide Synthase 3-Dependent Mechanism in Mice

Minamishima S, Bougaki M, Sips PY, Yu JD, Minamishima YA, Elrod JW, Lefer DJ, Bloch KD, Ichinose F. Circulation. 2009 Sep 8;120(10):888-96. doi: 10.1161/CIRCULATIONAHA.108.833491. Epub 2009 Aug 24.

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Hydrogen Sulfide Reviews

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The physiological role of hydrogen sulfide and beyond

Kimura H. Nitric Oxide. 2014 Sep 15;41:4-10.

 

Hydrogen Sulfide, the Next Potent Preventive and Therapeutic Agent in Aging and Age-Associated Diseases

Zhang Y, Tang ZH, Ren Z, Qu SL, Liu MH, Liu LS, Jiang ZS. Mol Cell Biol. 2013 Mar;33(6):1104-13. doi: 10.1128/MCB.01215-12. Epub 2013 Jan 7. Review.

 

Hydrogen Sulfide in Biochemistry and Medicine

Predmore BL, Lefer DJ, Gojon G. Antioxid Redox Signal. 2012 Jul 1;17(1):119-40. Review.

 

Physiological Implications of Hydrogen Sulfide: a Whiff Exploration that Blossomed

Wang R.  Physiol Rev. 2012 Apr;92(2):791-896. doi: 10.1152/physrev.00017.2011. Review.

 

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

Wallace JL, Wang R. Nat Rev Drug Discov. 2015 May;14(5):329-45

 

Emerging Role of Hydrogen Sulfide in Health and Disease: Critical Appraisal of Biomarkers and Pharmacological Tools

Whiteman M, Le Trionnaire S, Chopra M, Fox B, Whatmore J. Clin Sci (Lond). 2011 Dec;121(11):459-88. doi: 10.1042/CS20110267. Review.

 

Emergence of Hydrogen Sulfide as an Endogenous Gaseous Signaling Molecule in Cardiovascular Disease

Polhemus DJ, Lefer DJ. Circ Res. 2014 Feb 14;114(4):730-7. doi: 10.1161/CIRCRESAHA.114.300505.

 

Anti-inflammatory and cytoprotective properties of hydrogen sulfide

Burch G., Wallace JL.  Chapter 9 in Cadenas E and Packer L (editors), Methods in Enzymology, Vol. 555 "Hydrogen Sulfide in Redox Biology Part B", 2015, El Sevier- Associated Press, Amsterdam, p.185

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